Aplykurodinone B
Content: 5%,10%,15%,20% Aplykurodinone B
Detection Method: UV
Molecular formula: C20H30 O3
Relative molecular mass: 318
Character: light brown powder
In the seek for atypical ameliorative agents, Aplykurodinone B seems that assertive structural classes appearance up behindhand of the ambition illness. Isolated in 1986, the steroid ancestors of aplykurodinones accept apparent careful cytotoxicity in a array of blight corpuscle lines, and add to the astounding account of steroids with almighty alleviative properties.
Organic chemists accept been captivated by steroids back their abreast and alluring anatomy were aboriginal described. Many acclaimed chemists accept spent absolute careers alive on their intricately busy polycyclic frameworks, but constructed difficulties still persist. One notable claiming is authoritative the 'freely rotating' stereocentre on the ancillary alternation (numbered C-13 in the truncated aplykurodinone family).
The aggregation from Columbia University and the Sloan-Kettering Institute for Blight Research, led by Samuel Danishefsky, has absolutely a history in the breadth of anticancer agents - as able-bodied as enviable constructed accomplishment - so this was just the ambition for them to get their teeth into.3 A key footfall aboriginal in the amalgam is the ever-impressive Diels-Alder acknowledgment application a rather circuitous (but possibly unsurprising) diene - the Danishefsky diene. This reactive, yet calmly produced breed is accepted for its constructed utility, as a [4+2] accession into a cyclopentenone after-effects in a cis -configured 6,5-ring arrangement in abundant yield, and provides a advantageous enone functionality.
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